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After upgrading from 5.2.20 to 6.1.12, I have no sound no matter what guest I use, despite the log showing it's connecting successfully to the ALSA output. I've tried running the commandsuggested by others for this situation, but it doesn't resolve the issue(I've also tried other numbers between 50 and 250 to no avail). I thought it might be my .asoundrc, but eliminating it causes VirtualBox to complain it can't find the device "default" and a simplified one pointing directly at the hardware makes it give errors that the device is busy(despite there not being any other open applications open that could produce audio). I've attached the log of starting XP, attempting to play a sound from the sound panel and shutting it down again, which only shows expected error related to attempting to open the ALSA default as an input. Normally I'd just revert back to 5.2.20, but the modules suddenly stopped building on the same kernel they'd built on before.

Hi,
encountered the same problem after yesterdays dnf update (of Fedora 32) with a windows 7 guest.

I then downgraded to VirtualBox-6.1.x86_64-6.1.10_138449_fedora32-1 but still I have no audio

I am using a plantronics headset that is connect to the host.
The audio device "high definition audio device" is not working as shown in the device manager under windows.