virtualbox.org

I hear - Chrome OS is most secure system, but in my Job I use Linux.
Best solution will Laptop with Chrome OS and Linux guest on Virtual Box
It is possible?

ChromeOS *is* Linux based, so I'm not sure what you're talking about. The kernel for ChromeOS is Linux, but it's targetted to tablets, not desktops. I'm not sure if you can install VirtualBox in ChromeOS.

I believe you're looking at it the wrong way.