OK to clear things up: I'am starting virtual machines with a script in fullscreen mode
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VBoxManage startvm "win10" -type GUI
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If the guest system has guest additions installed, mouse integration (MI) kicks in whenever the machine is started. Even when MI is deactivated in the GUI (after leaving fullscreen mode) by hand during the session, this particular setting is not remembered by VirtualBox between sessions.
Why do I want to disable MI anyway: When plugging in an USB-Mouse on my Notebook with Touchpad while the VM is running I get a ghost cursor: There is no iconic representation of the USB-Mouse Pointer visible, even if it works (you see the hover effects and you can successfully click elements on the guest desktop. The visible Mouse Pointer follows the movements on the Touchpad.
If there are still questions to my problem, please ask.
Thanks,
Frank