virtualbox.org

Hello I have a big problem

I have VirtualBox and Windows 10 but when I try to start a game it makes me : "Sorry, this application cannot run under a virtual machine"

How to solve the problem?

The only way to solve that problem is to approach the game developer and ask for a version that allows itself to be run inside a VM.

There are many ways (easy and complex) for software to detect that it's running in a VM. It can't be prevented from detecting the VM. If the developers choose to exit the app when it detects a VM then that's it.