The Virtual Box server log shows the titular error in its logs:
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VirtualBox COM Server 5.0.12 r104815 win.amd64 (Dec 18 2015 16:07:28) release log
00:00:00.066003 main Log opened 2015-12-22T04:17:31.645138100Z
00:00:00.066003 main Build Type: release
00:00:00.066003 main OS Product: Windows 7
00:00:00.066003 main OS Release: 6.1.7601
00:00:00.066003 main OS Service Pack: 1
00:00:00.100005 main DMI Product Name: X8DA3
00:00:00.113006 main DMI Product Version: 1234567890
00:00:00.113006 main Host RAM: 24566MB total, 12905MB available
00:00:00.113006 main Executable: C:\Program Files\Oracle\VirtualBox\VBoxSVC.exe
00:00:00.113006 main Process ID: 14224
00:00:00.113006 main Package type: WINDOWS_64BITS_GENERIC
00:00:00.117006 Home directory: 'D:\Users\me/.VirtualBox'
00:00:00.118006 Loading settings file "D:\Users\me/.VirtualBox\VirtualBox.xml" with version "1.11-windows"
00:00:02.701154 Getting USB descriptor failed with error 995
00:00:04.701268 Getting USB descriptor failed with error 995
00:00:07.701440 Getting USB descriptor failed with error 995
00:00:07.959455 HostDnsMonitor: old information
00:00:07.959455 no server entries
00:00:07.959455 no search string entries
00:00:07.959455 no domain set
00:00:07.959455 HostDnsMonitor: new information
00:00:07.959455 server 1: 192.168.xxx.xxx (Correct data was there.)
00:00:07.959455 no search string entries
00:00:07.959455 domain: xxxxxxxx (Correct data was there.)
00:00:07.959455 HostDnsMonitorProxy::notify
00:00:08.146465 VD: VDInit finished
00:00:08.149466 Loading settings file "D:\VBox\Wibbler\Wibbler.vbox" with version "1.12-windows"
00:00:08.150466 Loading settings file "D:\VBox\Minty\Minty.vbox" with version "1.12-windows"
00:00:08.151466 Loading settings file "D:\VBox\SL6\SL6.vbox" with version "1.12-windows"
00:00:08.153466 Loading settings file "D:\VBox\FC17 64\FC17 64.vbox" with version "1.12-windows"
00:00:08.155466 Loading settings file "D:\VBox\Win7-32\Win7-32.vbox" with version "1.12-windows"
00:00:08.157466 Loading settings file "D:\VBox\Wednesday2\Wednesday2.vbox" with version "1.14-windows"
00:00:08.158466 Loading settings file "D:\VBox\Win8.1 thingie\Win8.1 thingie.vbox" with version "1.14-windows"
00:00:08.159466 Loading settings file "D:\VBox\SL6p5\SL6p5.vbox" with version "1.14-windows"
00:00:08.161466 Loading settings file "D:\VBox\Haiku v1 Alpha 4\Haiku v1 Alpha 4.vbox" with version "1.15-windows"
00:00:08.643494 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.643494 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.644494 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.644494 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.655495 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.655495 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.658495 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.658495 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.668495 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.668495 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.673496 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.673496 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.673496 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.673496 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.678496 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.678496 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.680496 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.680496 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:00:08.685496 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Unknown exception
00:00:08.685496 F:\tinderbox\win-5.0\out\win.amd64\release\obj\VBoxAPIWrap\MediumWrap.cpp[2245] (long __cdecl MediumWrap::GetEncryptionSettings(unsigned short **,unsigned short **))}, preserve=false aResultDetail=0
00:01:21.061636 Watcher ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={f30138d4-e5ea-4b3a-8858-a059de4c93fd} aComponent={MachineWrap} aText={The virtual machine 'Wibbler' has terminated unexpectedly during startup with exit code 1 (0x1). More details may be available in 'D:\VBox\Wibbler\Logs\VBoxHardening.log'}, preserve=false aResultDetail=0
00:01:26.197930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Wibbler\XP Master.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.197930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Wibbler\D Drive.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.197930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Wibbler\E Drive.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.197930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'J:\WEDNESDAY2-C.VHD' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.198930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Minty\Linux Mint.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.198930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\SL6\SL6.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.199930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\FC17 64\FC17 64.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.199930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Win7-32\Snapshots/{43c2968a-7f30-4964-a3a6-0b3e0b390f6c}.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.199930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Win7-32\Win7-32.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.200930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'J:\WEDNESDAY2-DE.VHD' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.200930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'F:\VBoxish\Win8.1 thingie.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.200930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\SL6p5\SL6p5.vhd' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.201930 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={4afe423b-43e0-e9d0-82e8-ceb307940dda} aComponent={MediumWrap} aText={Medium 'D:\VBox\Haiku v1 Alpha 4\Haiku v1 Alpha 4.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false aResultDetail=0
00:01:26.203930 Watcher ERROR [COM]: aRC=E_ACCESSDENIED (0x80070005) aIID={0169423f-46b4-cde9-91af-1e9d5b6cd945} aComponent={VirtualBoxWrap} aText={The object is not ready}, preserve=false aResultDetail=0{^_^}