According to this thread, this points to a buggy driver:
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Anyone else that have seen this problem, and if you have not noticed it yet, can you take a look with RAMMap if you find your memory use a bit high (not a member long enough to post real urls
Do you also have a lot of processes no longer in task manager, but in the processes tab of RAMMap?
Any suggestions on how to further investigate this issue. Can I try to reload some VirtualBox driver without rebooting to see if the memory is released?