Would you want to do extensive business in Chinatown if you didn't know Chinese? Or Little Italy / Italian? I and my family speak full-blown American English. But my oldest daughter would do Chinatown - she taught herself Chinese. Started at 14, first time she spoke it in public at 18 they said she sounded like she'd been tutored for seven years (brag off)

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All the modern usual OSs can run Virtualbox easily. And every modern OS has a desktop and a point/click interface for Virtualbox. Windows is Windows, slight differences in desktop between 7,8,8.1,10, depending on when you are willing to let support run out. Many of the Linux flavors seem to me to be based on what kind of desktop environment or licensing philosophy the developers/users live by. They'll all fly at running Virtualbox.
But maybe this could be the defining question: Which programming and command window language are you comfortable with or willing/have time to learn? Eventually running guests gets into using the command line & scripts if you really get into it. If one skips the desktop and goes text-only to have more resources for guests, then the command line even more comes into play. Which language do you cmd? Pick the OS that cmd's the same language.