In my log i have this:
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VirtualBox COM Server 4.3.6 r91406 win.amd64 (Dec 18 2013 17:12:34) release log
00:00:00.005000 main Log opened 2014-02-08T01:58:57.609093400Z
00:00:00.005000 main Build Type: release
00:00:00.005000 main OS Product: Windows 7
00:00:00.005000 main OS Release: 6.1.7601
00:00:00.005000 main OS Service Pack: 1
00:00:00.115006 main DMI Product Name: System Product Name
00:00:00.127007 main DMI Product Version: System Version
00:00:00.127007 main Host RAM: 16281MB total, 10313MB available
00:00:00.127007 main Executable: C:\Program Files\Oracle\VirtualBox\VBoxSVC.exe
00:00:00.127007 main Process ID: 8932
00:00:00.127007 main Package type: WINDOWS_64BITS_GENERIC
00:00:00.130007 Loading settings file "C:\Users\kon/.VirtualBox\VirtualBox.xml" with version "1.12-windows"
00:00:00.344019 VDInit finished
00:00:00.345019 Loading settings file "C:\Users\kon\VirtualBox VMs\Ubuntu 11.10 Server\Ubuntu 11.10 Server.vbox" with version "1.12-windows"
00:00:05.349306 main ERROR [COM]: aRC=VBOX_E_OBJECT_IN_USE (0x80bb000c) aIID={05f2bbb6-a3a6-4fb9-9b49-6d0dda7142ac} aComponent={Medium} aText={Medium 'C:\Users\kon\VirtualBox VMs\Ubuntu 11.10 Server\Ubuntu 11.10 Server.vdi' cannot be closed because it is still attached to 1 virtual machines}, preserve=false
00:00:10.351592 Watcher ERROR [COM]: aRC=E_ACCESSDENIED (0x80070005) aIID={fafa4e17-1ee2-4905-a10e-fe7c18bf5554} aComponent={VirtualBox} aText={The object is not ready}, preserve=false
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VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code E_NOINTERFACE (0x80004002) - No such interface supported (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start.
I have checked permissions, component services/typelib entries and didn't see anything out of the order.
Any ideas and pointers what could be wrong here?
What would be a good method to further trace down the cause of this error?