I get this error message when trying to install (after entering my Mac OS password):
Failed to install the Extension Pack /Users/aheinon/Downloads/Oracle_VM_VirtualBox_Extension_Pack-4.2.0-80737.vbox-extpack.
Failed to load the main module ('/Applications/VirtualBox.app/Contents/MacOS/ExtensionPacks/Oracle_VM_VirtualBox_Extension_Pack/darwin.amd64/VBoxPuelMain.dylib'): VERR_FILE_NOT_FOUND - dlopen(/Applications/VirtualBox.app/Contents/MacOS/ExtensionPacks/Oracle_VM_VirtualBox_Extension_Pack/darwin.amd64/VBoxPuelMain.dylib, 6): Library not loaded: /Applications/VirtualBox.app/Contents/MacOS/VBoxVMM.dylib
I had the exact same issue. Turns out the update to 4.2 somehow DOES NOT overwrite the 4.1 application, and when you start VirtualBox from Spotlight 4.1 gets started again. I had to do a full uninstall and purge everything, and check under File -> About VirtualBox to make sure the right version of VirtualBox was running.