I'm really not sure what "*.vbox" file I should be looking for. I'm not seeing any ".vbox" file extensions in my directory (this is windows)...
All of my files in the C:\Program Files\Oracle\VirtualBox directory are dated no later than yesterday, and there are five subdirectories with today's date (nls, doc, drivers, sdk, accesible).
Given I can't find the file you are refering to, I don't see how I can edit it

.
And rebooting the system didn't allow me to delete the .ISOs from the Virtual Media Manager, but like I said, they are not "attached" so I'm not sure that it's the crux of the problem...
I think I may need to try to roll back to ver 4.1.6...I'm running out of time and if I can't get to the work I saved there soon, I'm in big trouble...