Well, it's going to be a long story
You are right, Moxa is a serial to usb converter, except mine model is 1130. But it doesn't matter, since it's a common problem, I believe.
Short intro. Since I'm service engineer and my new "modern" laptop doesn't have serial input I'm forced to use converter. I also use VM because of the policy restrictions on my host machine. Now regarding the issues I have with Moxa converter. There are 2 problems.
1. Connecting the Moxa to guest machine
2. Recognizing the Moxa by guest machine
I use:
@ host >> Windows 7 Pro 7601.win7sp1_ldr.170427-1518.
@ guest >> Windows 7 Ent 7601.win7sp1_ldr.170427-1518. Both versions are legal. No cracks or whatsoever. Guest Windows is freshly installed.
VM Version 5.1.22 r115126 (Qt5.6.2)
More detailed info from cmd.exe see in the attached zip file.
Outputs from cmd.exe in txt files
The problem #1. In the beginning I had a problem connecting Moxa to guest. Why? I don't know, but I know how to fix it temporarily. Why temp? Because the problem will appear again in the future.
I'm getting this error when I try to connect the USB device to guest.

- 1.png (22.37 KiB) Viewed 11036 times
Even though the status shows Captured, but the device doesn't appear in the Device Manager.

- 2.png (70.87 KiB) Viewed 11036 times
Workaround for Windows 7 is to re-install VM's USB drivers:
1. Shut down active VM
2. In Oracle VM Manager app go to File->Reset All Warnings
3. Close Oracle VM Manager app
4. Go to C:\Program Files\Oracle\VirtualBox\drivers\USB\filter
5. Right Click on VBoxUSBMon.inf
6. Click Install
7. Open Oracle VM Manager app. Run VM. Use filter or get it on the fly. Both options will work.
8. Done. USB device is captured.
Now when Problem #1 is fixed I have another problem #2 which is the subject of this thread, but I believe this one is due to the lack of my knowledge in VMs.
The problem is that even though device is recognized, it cannot be started (Code 10). As it doesn't have any COM ports available in the Driver settings (see attached image). I tried to enable COM port (Host Device mode) in the VM and show the path/address to the actual COM port on the Host machine but it didn't work.
I'm actually stuck at this point and continue to experiment with the settings. If you know the solution, please help.