When you ask a CentOS 5.6 guest (64-bit) to shut down or reboot, it hangs Virtualbox (host is Windows XP).
I'm using the latest Virtualbox 4.0.10 and installed guest additions.
Copy/paste to Centos also fails, but only hangs for a little while.
Debian (sid, 64-bit) seems to work fine as a guest in VirtualBox though...no problems rebooting at all