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after installing the guest additions 4.08r71778 on thw Windows 2K guest machine and rebooting, it gives me the error "the service database is locked" and the drivers fail to install. How do I resolve this?

Have you admin rights in the windows guest?

I ran into a similar problem with Windows XP SP3 as the guest OS. It failed to install the guest driver. I was able to get around this issue by booting into safe mode and trying again. It might be a little late for you to try it. But maybe this will help someone else.

Same problem here; Mac OSX 7.2, Windows Vista guest, "service database is locked" -- but after the third time I tried installing it, it worked ok. No idea why.

This is a well-known Windows message and has nothing to do with VirtualBox. eg http://support.microsoft.com/kb/214762