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I unable to create a Win10 Pro VM on Centos 8, which is running on a Dell Poweredge R815 Server.
I am allocating 256GB and 32 CPUs for the VM (not sure if this has any bearing).
Windows boots and start the installation process but at random times fails with a Guru Error.

I am ujnsure of how to proceed.

00:04:47.169482 emR3Debug: rc=VERR_NO_MEMORY
00:36:58.965148 GUI: Request to close active machine-window.
00:36:58.965655 ERROR [COM]: aRC=VBOX_E_INVALID_VM_STATE (0x80bb0002) aIID={872da645-4a9b-1727-bee2-5585105b9eed} aComponent={ConsoleWrap} aText={Invalid machine state GuruMeditation when checking if the guest entered the ACPI mode)}, preserve=false aResultDetail=0
00:48:13.892953 GUI: Request to close active machine-window.
00:48:13.893340 ERROR [COM]: aRC=VBOX_E_INVALID_VM_STATE (0x80bb0002) aIID={872da645-4a9b-1727-bee2-5585105b9eed} aComponent={ConsoleWrap} aText={Invalid machine state GuruMeditation when checking if the guest entered the ACPI mode)}, preserve=false aResultDetail=0
00:48:30.642931 GUI: Request to close active machine-window.
00:48:30.643262 ERROR [COM]: aRC=VBOX_E_INVALID_VM_STATE (0x80bb0002) aIID={872da645-4a9b-1727-bee2-5585105b9eed} aComponent={ConsoleWrap} aText={Invalid machine state GuruMeditation when checking if the guest entered the ACPI mode)}, preserve=false aResultDetail=0
00:49:44.970589 GUI: Request to close active machine-window.
00:49:44.971024 ERROR [COM]: aRC=VBOX_E_INVALID_VM_STATE (0x80bb0002) aIID={872da645-4a9b-1727-bee2-5585105b9eed} aComponent={ConsoleWrap} aText={Invalid machine state GuruMeditation when checking if the guest entered the ACPI mode)}, preserve=false aResultDetail=0
00:49:46.799382 GUI: Request for close-action to power VM off.
00:49:46.799558 GUI: Passing request to power VM off from machine-logic to UI session.
00:49:46.799605 GUI: Powering VM down on UI session power off request...
00:49:46.801341 Console: Machine state changed to 'Stopping'

Log snippets wont help, but the whole zipped log might. Use the Upload Attachment tab.

Also, try 2 processors and 4GB RAM for a start, then increase as needed. VMs aren't like bare metal, in that more processors can have adverse effect due to extra scheduling oversight needed on the host. Processor count should be tuned to the load.