After upgrading my host Ubuntu 20.04 to Ubuntu 21.04, I am having issues with the mouse (touchpad).
Symptoms
* Cursor moves properly for host and guest (good).
* Problem sometimes does not happen right away. At first, it works fine.
* Later, touchpad click does nothing for host and guest
System
* VirtualBox Version 6.1.26 r145957 (Qt5.15.2) installed from virtualbox.org
* VirtualBox extension pack 6.1.26r145957
* Host: Ubuntu 21.04
* Guest: Windows 10 20H2 and other Windows 10 builds
* Hardware: Lenovo IdeaPad 330s-15ikb
* Single screen
* Guest is set to USB Tablet
Steps I tried
* Search for solutions online
* While VM is running, disable and reable mouse integration
* Plug in hardware USB mouse, unplug it, and plug it back
* Use touchpad instead of mouse.
* Put guest in full screen or windowed mode
* Reboot guest
* Reboot host
* Look for VBoxClient to kill, but it did not exist https://www.virtualbox.org/ticket/14903