Same issue here. All existing virtual machines complain about invalid network adapter.
This was an upgrade from 4.1.18 (Windows 7 64bit host).
Interestingly enough, the issue has only appeared after a reboot. After initial install I didn't reboot and all virtual machines worked as expected.
The logfile reports:
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00:00:01.402558 AssertLogRel E:\tinderbox\win-rel\src\VBox\Main\src-client\ConsoleImpl2.cpp(4000) int __cdecl Console::configNetwork(const char *,unsigned int,unsigned int,struct INetworkAdapter *,struct CFGMNODE *,struct CFGMNODE *,struct CFGMNODE *,bool,bool): <NULL>
00:00:01.402571 NetworkAttachmentType_Bridged: FindByName failed, rc=E_INVALIDARG (0x80070057)VMSetError: E:\tinderbox\win-rel\src\VBox\Main\src-client\ConsoleImpl2.cpp(4001) int __cdecl Console::configNetwork(const char *,unsigned int,unsigned int,struct INetworkAdapter *,struct CFGMNODE *,struct CFGMNODE *,struct CFGMNODE *,bool,bool); rc=VERR_INTERNAL_ERROR
00:00:01.405107 VMSetError: Nonexistent host networking interface, name 'Intel(R) 82577LM Gigabit Network Connection'
00:00:01.405600 ERROR [COM]: aRC=E_ACCESSDENIED (0x80070005) aIID={db7ab4ca-2a3f-4183-9243-c1208da92392} aComponent={Console} aText={The virtual machine is not powered up}, preserve=false
00:00:01.557518 ERROR [COM]: aRC=E_FAIL (0x80004005) aIID={db7ab4ca-2a3f-4183-9243-c1208da92392} aComponent={Console} aText={Nonexistent host networking interface, name 'Intel(R) 82577LM Gigabit Network Connection' (VERR_INTERNAL_ERROR)}, preserve=false
After a full uninstall, reboot, reinstall things are working as expected