Cannot create new vm

Install VirtualBox-5.1.8-111374-Win as Admin on Windows 7. Appears to install without issue. But when trying to create new VM (several configurations tried) I get
This is my first time using VirtualBox, so I don't know where to begin debugging this. Any help welcome.
Failed to acquire the VirtualBox COM object. The application will now terminate.
Failed to instantiate CLSID_VirtualBox w/ IVirtualBox, but CLSID_VirtualBox w/ IUnknown works.
PSDispatch looks fine. Weird.
Result Code: E_INVALIDARG (0x80070057)
Component: VirtualBoxClientWrap
Interface: IVirtualBoxClient {d2937a8e-cb8d-4382-90ba-b7da78a74573}
This is my first time using VirtualBox, so I don't know where to begin debugging this. Any help welcome.