Well, it looks that
I actually have a problem with 5.0.10
NAT isn't working anymore. I'm primarily using VB on a network which has Microsoft Forefront TMG as proxy/firewall (it's actually in the process to be replaced, probably by first months of 2016).
I do have full admin access on TMG and enabling the logging I do not see any errors but I do not see any "real traffic" too, just the start/close session
Googling I have found this bug report
https://www.virtualbox.org/ticket/13292 where (
what a surprise 
) the hardening feature seems involved.
On my pc I have the Forefront TMG Client installed and enabled, could it be that its DLLs are being blocked?
In the logs there are many references to these DLLs, like the following.
1388.1bb0: supHardenedWinVerifyImageByHandle: -> 0 (\Device\HarddiskVolume2\Program Files\Forefront TMG Client\FwcWsp.dll) WinVerifyTrust
1388.1bb0: supR3HardenedWinVerifyCacheInsert: \Device\HarddiskVolume2\Program Files\Forefront TMG Client\FwcWsp.dll
1388.1bb0: supR3HardenedMonitor_LdrLoadDll: pName=C:\Program Files\Forefront TMG Client\FwcWsp.dll (rcNtResolve=0xc0150008) *pfFlags=0x0 pwszSearchPath=007c7b5c:C:\Program Files\Oracle\VirtualBox;C:\Windows\system32 [calling]
1388.1bb0: supR3HardenedScreenImage/NtCreateSection: cache hit (VINF_SUCCESS) on \Device\HarddiskVolume2\Program Files\Forefront TMG Client\FwcWsp.dll
1388.1bb0: supR3HardenedDllNotificationCallback: load 74bb0000 LB 0x001fc000 C:\Program Files\Forefront TMG Client\FwcWsp.dll [fFlags=0x0]
1388.1bb0: supR3HardenedScreenImage/LdrLoadDll: cache hit (VINF_SUCCESS) on \Device\HarddiskVolume2\Program Files\Forefront TMG Client\FwcWsp.dll