I have used the Win32 guest and this same USB device for more than a year. The Win32 guest has worked with at least three versions of Virtualbox. I have noticed that the Virtualbox USB device no longer appears in the "Devices and Printers" Control Panel page on the Windows 10 system. From within the Win32 guest, I even ran "VBoxWindowsAdditions-x86 /extract /D=C:\Drivers".Result Code: E_INVALIDARG (0x80070057)
Component: HostUSBDeviceWrap
Interface: IHostUSBDevice {c19073dd-cc7b-431b-98b2-951fda8eab89}
Callee: IConsole {872da645-4a9b-1727-bee2-5585105b9eed}.
Any ideas?